AI ANALYSIS: The Bills face a challenging road environment against a Broncos team that finished with an impressive 14-3 record. Buffalo's injury report shows they'll be without key defensive contributors including linebacker Terrel Bernard and safety Damar Hamlin, while running back Ty Johnson is questionable with an ankle injury. Denver benefits from home field advantage and a strong regular season performance, making them slight favorites. The Broncos' solid home record and healthier roster give them the edge in what should be a close, low-scoring playoff battle.

AI ANALYSIS: The Patriots dominated the regular season with a 15-3 record and have the advantage of playing at home in this matchup. New England's injury report shows cornerback Alex Austin and defensive lineman Khyiris Tonga are out, but they have most key players available. The Texans are dealing with running back Jawhar Jordan being out with an ankle injury, which could limit their ground game options. New England's superior regular season performance and home field advantage should carry them to victory in a defensive struggle.

AI ANALYSIS: The 49ers enter with a strong 13-5 record and face a Seattle team that finished 14-3 but may be vulnerable in this divisional matchup. San Francisco's injury concerns center around left tackle Trent Williams, who is questionable with a hamstring injury but is expected to play after limited practice participation. The 49ers' playoff experience and offensive weapons should give them a slight edge over Seattle. Despite Seattle's home field advantage and excellent regular season record, the 49ers' championship pedigree and balanced attack will prove decisive in a high-scoring NFC West showdown.

AI ANALYSIS: The Bears finished with a solid 12-6 record and benefit from home field advantage at Soldier Field in January conditions. Chicago's recent playoff momentum after defeating Green Bay in the wild card round gives them confidence heading into this matchup. The Rams, despite their 13-5 record, face the challenge of playing in potentially harsh weather conditions that could favor the Bears' running game and defense. Chicago's strong home performance during the regular season and their recent playoff victory should propel them to another postseason win in front of their home crowd.